爱情和失落伴随着两位出色的女性：Karen Crespo和Nicole Evans。 这两名妇女都身体残疾; 然而，妮可出生时残疾，而凯伦后来成为残疾人。 出生时残疾与后来成为残疾人之间存在巨大差异。 妮可过去30年来应对并学会接受她的残疾，而凯伦几乎在一夜之间处理了身体和情感创伤。 尽管他们进行了试验，但这些女性正在采取措施在他们的生活中寻找爱情 通过观察他们的约会生活，这部电影探讨了身体受损个体的挑战性和非常规的亲密关系，以及这些人如何在他们的残疾背景下定义和生活。

Love & Loss follows two surprisingly strong women: Karen Crespo & Nicole Evans. Both women are vibrantly physically disabled; however, Nicole was born disabled while Karen became disabled later in life. There is a tremendous difference between being born with a disability and becoming disabled later. Nicole has had the past 30 years to cope with and learn to embrace her disability while Karen had deal with both the physical and emotional trauma almost overnight. Despite their trials, these women are taking steps to find love in their lives. Through the observation of the dating lives of theirs, this film explores the challenging and often unconventional intimate relationships of physically-impaired individuals, as well as how those individuals define and live their lives within the context of their disabilities.